Neurotransmitter: Summer 2017
Sign up for the CBTF Newsletter Issued quarterly, our newsletter offers recent articles and events, features, and more!
Neurotransmitter: Spring 2017
Sign up for the CBTF Newsletter Issued quarterly, our newsletter offers recent articles and events, features, and more!
Larry and Judith, the Dynamic Duo
Courage, determination and compassion are words that come to mind when thinking about twins Larry and Judith Theriault of Peabody, Massachusetts. Now thirteen years old, Larry and Judith are living with neurofibromatosis (NF 1). They were diagnosed at 6 months of age and first manifested optic nerve gliomas at age 2 and 3 respectively. Larry …
Memories of a Childhood Brain Tumor
I was a senior in high school and had not been feeling “well” all year. However, my complaints were relatively non-specific which made it difficult for my doctors to pinpoint the “real” problem. Anything can cause chronic fatigue and headaches they told me and, as for the intermittent numb, tingling on my left side … …
MR Imaging of Brain Tumors
Recent Developments Gilbert Vezina, M.D., Director of Neuroradiology – Children’s National Medical Center, Washington D.C. Imaging techniques to diagnose, stage, and follow patients with brain tumors are central to their clinical management. Magnetic resonance imaging (MRI) is the most commonly utilized technique for lesion detection, definition of extent, detection of spread and in evaluation of …
Neurotransmitter: Summer 2016
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Aberrant Epigenetic Control of Notch Signals in Medulloblastoma
Jean-Francois Rual, Ph.D. University of Michigan Progress Update from 1st year: 8/1/2014-7/30/2016 Millions of cells are formed every day in the developing brain of children. Medulloblastoma, the most common and ag-gressive form of pediatric brain tumor, occurs when the proliferation of cells in the cerebellum becomes uncontrolled, The Notch path-way is a key mechanism that …
Multispecific CAR T cells for the Treatment of High Grade Gliomas in Children
Kevin Bielamowicz, M.D., Arkansas Research Institute 2016, second year Poor outcomes for children with high grade glioma (HGG) warrant novel therapeutic strategies, and redirecting immune cells can achieve this aim while minimizing side effects to normal cells. Using mathematical modeling in a group of brain tumor samples, we discovered substantial variation between individual cells within …
Targeting pediatric glioblastoma (pGBM) by debiquitinase inhibition
Hai-Ri Song, M.D., Assistant Professor, Department of Neurosurgery/Neurology, New York University School of Medicine one year, 2016 In spite of dramatic advances in the cure rate for most childhood malignancies, the prognosis for children with brain tumors is exceedingly poor. The urgent need for novel therapy is underscored by the fact that brain tumors are …