The 17th International Symposium on Pediatric-Oncology was held in Liverpool, ENGLAND, June 12-15, 2016. The Childhood Brain Tumor Foundation was pleased to be a Silver Sponsor of the comprehensive meeting, sponsoring a couple of sessions. The event had a record turnout. The summer newsletter will feature a session from Family Day, held on June 11, …
2016 Summary Principal investigators: Dimitris Placantonakis and Jayeeta Basu, NYU School of Medicine Glioblastoma (GBM) is a deadly brain tumor affecting children and adults. The biology of GBM is not well understood and, as a consequence, treatments are limited and ineffective. GBM grows rapidly and invades normal brain tissue, but never metastasizes to other organs. …
November 20 – 22, 2015 For the second year, HC Elite of Howard County held a Fall Ball Basketball Tournament in memory of Ricky Knight who passed away in 2008 at the age of 12. Ricky Knight was diagnosed with a Glioblastoma Multiforme brain tumor at the age of 11 in 2007. He fought courageously …
Claudia Petritsch, Ph.D. Funded 2015, second year BRAF Mutation effects on malignant astrocytoma development and therapy responses. Abstract: CD133+ subpopulations of cells in glioblastoma (GBM) show in vivo resistance to treatment with radiation and temozolomide, and are thought to contribute to therapy evasion and tumor recurrence. Frequent hyperactivation of the MAPK pathway in GBM has …
Rheal Towner, Ph.D., Oklahoma Medical Research Foundation Progress Update from 2nd year: 9/2012-8/2014 The Childhood Brain Tumor Foundation funded project, Novel Agent for Pediatric Glioblastomas (pGBMs), headed by Dr. Rheal Towner at the Oklahoma Medical Research Foundation, is assessing a novel agent, Oklahoma Nitrone 007 (OKN-007), in pre-clinical mouse models for pediatric glioblastomas (pGBs). Patient-derived …
Hello Everyone, My name is Jason Shook and I am glad to say that I have been in remission for twenty two years. I am grateful to have the opportunity to share some of my life’s experiences with you all today. In January of 1991 at age eleven I was diagnosed with medulloblastoma by the …
Marius Wernig, M.D., Ph.D. Stanford University School of Medicine The lysine 27 to methionine substitution in histone variant H3.3 (H3.3-K27M) is the most common mutation in pediatric high grade gliomas. Recent studies have demonstrated that this mutation leads to a global reduction of H3K27 trimethylation in a dominant manner by sequestering an enzymatic subunit of …
In his 7 1/2 years on this earth, Jared Forman lived his life to the fullest. When he was around, you couldn’t help but smile, especially after noticing his gorgeous blonde hair and beautiful blue eyes. His personality was that of no other. He was very boisterous, witty, and one of kind. Jared would tell …
Fausto J. Rodriguez, M.D., Johns Hopkins University School of Medicine Progress Update: One-year funding, 9/2013-8/2014 The main goal of this proposal is to compare changes in the abundance of a group of molecules that have been recently discovered and named “microRNAs” in pilocytic astrocytoma (PA), the most frequent low grade glioma in children. MicroRNAs are …
