Rajeev Vibhaker, M.D., Ph.D. University of Colorado Progress Update: 9/2012-8/2014 We have completed the initial set of studies to examine the role of MPS1 in controlling medulloblastoma cell division and validated a therapeutic target. We demonstrated that MPS1 is critical for cell division of tumor cells and both genetic and chemi-cal inhibition of MPS1. Several …
The Childhood Brain Tumor Foundation proudly was a Silver Sponsor of the 16th International Symposium on Pediatric Neuro-Oncology, a biennial meeting. The meeting was held June 28 through July 2, 2014. The ISPNO Conference in Singapore was attended by over 900 clinicians and clinical and basic science researchers in neuro-oncology. By design, the conference’s plenary …
Claudia Petritsch, Ph.D., The Regents of the University of California Funding duration 2012-2014, Program Summary Studies have shown that a mutant activated form of BRAF, BRAFV600E, and concomitant homozygous deletion of CDKN2A occur in a subset of pediatric malignant astrocytomas. Importantly, BRAFV600E transforms CDKN2A-deficient neural progenitor cells and BRAF kinase is involved in signaling pathways …
Jezabel Rodriguez-Blanco, Ph.D. Postdoctorate Associate, Molecular Oncology The DeWitt Daughtry Family Department of Surgery Progress Update: 9/2013-8/2015 Medulloblastoma (MB) is a highly malignant brain tumor affecting predominantly children. MB arises from granular progenitors that after cerebella development do not respond to cellular cues to stop functioning, resulting in them becoming cancer stem/progenitor cells (CSC) that …
PI: Joseph Scafidi, DO – Children’s Research Institute, Washington, DC Grant duration, Aug. 2011 – Sept. 2013, review is update on progress The brain of children is subject to rapid growth and development. White matter is the part of the brain that is vital for communication and processing of information. White matter comprises nearly half …
Pamela L. Wolters, Ph.D., Neurobehavioral Program, National Cancer Institute Program duration 2012-2013, one-year Significant cognitive late effects are associated with cranial radiation therapy. Although treatment regimens have been modified in attempts to reduce neurotoxicity, limited research has focused on therapeutic interventions targeted toward ameliorating or preventing these impairments. One potential novel intervention for cognitive rehabilitation …
My name is Cordell Bartrum, I want to be a professional motocross racer, and I have an inoperable brain tumor. I was diagnosed when I was just three-years-old. I am now 16, and I want to call attention to this medical condition. My tumor is incurable due to its location. My mom said that she …
Riptide’s Benefit Concert and the Corned Beef Mafia’s Ride for Research in Honor of Kayla Wenger Jeanne Young and Eric Wenger Kayla enjoyed a normal childhood during her early years, much like her friends. She danced ballet, hula-hooped, jumped rope, played basketball, and played soccer. However, there was something different, and the difference in Kayla …
Sara Bottomley, RN, MSN, CPNP The survival rate of patients with childhood brain tumors continues to improve. However, survivors are at risk for a variety of physical, medical, cognitive, and/or psychosocial late effects. These late effects may be directly related to the type, location and extent of the brain tumor itself or a result of …
