by Loice Swisher, M.D., co-authored by Dr. Peter Philips New resources added at the end of this article. A child s loss of speech after removal of a cerebellar tumor was initially described in 1958 (Daly and Love 1958). Cerebellar mutism was first reported in 1979 by Hirsch after a posterior fossa tumor resection. In …
Michael X. Repka, M.D., Vice Chair for Clinical Practice, Wilmer Eye Institute, Professor of Ophthalmology, Johns Hopkins University School of Medicine, N. Wolfe Street, Baltimore, MD 21287-9028 Childhood brain tumors present with visual symptoms about 50% of the time. Additionally, children will develop visual symptoms and/or signs during and after treatment. Such signs may become …
Books often indicate that siblings of cancer patients frequently feel neglected. This however, was not the case with me. I have never once resented the cancer or my brother. Instead, I feel that I have learned from it. When my brother was diagnosed, with a brain tumor in 1991, I started checking out all the …
Daniel W. Lee, MD, University of Virginia Cancer Center Charlottesville One-year study, final summary 2019 Dr. Lee and his lab set out to develop a brand new tool to effectively treat children with DIPG. Using Chimeric Antigen Receptor (CAR) T cells, a therapy he helped pioneer in children with refractory leukemia, Dr. Lee’s lab designed, …
Yin Wang, Ph.D. First-year Children’s National, DC; University of Maryland, Baltimore Two-year study, second year Dr. Wang’s group has made significant progress for their project, “A Novel Mechanism and Immediately-Translatable Targeted-Therapy for Group 3 Medulloblastoma”. Their completed studies have demonstrated that HIF1α is a driver for infant Group 3 medulloblastoma (G3MB) by reciprocal positive regulation …
Huadong Pei, Ph.D., The George Washington University New Funding Summary, first of two years Medulloblastoma is the most common and aggressive type of brain tumor in children. It originates in the back part of the brain called the cerebellum. In up to 1/3 of cases, it can spread to other parts of the brain and …
Carl D. Novina, M.D., Ph.D.Dana-Farber Cancer Institute NEW-first of two-years 2019-2020 “The central organizing idea of biology (dogma) is that DNA (the blueprint of a cell), makes RNA (a messenger of information contained in the DNA) which in turn makes proteins (which carry out the activities of a cell). Whereas most scientists and physicians study …
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