Secret Life of the Brain: a 3-D Anatomy Tour Navigate through the brain and learn about how the brain functions.

Does Growth Hormone Cause Cancer? Clinical Endocrinology; P. J. Jenkins; A. Mukherjee; and S.M. Shalet A summary

Desmoplastic infantile ganglioglioma: novel aspects in clinical presentation and genetics. Surg Neurol. 2007 Sep;68(3):304-8; discussion 308. Desmoplastic infantile ganglioglioma is a rare tumor occurring mainly in infants and young children. Both radiological and histopathological appearances may resemble malignancy, although its clinical course is mainly benign.

Craniopharyngioma Informational site

Diffuse Intrinsic Pontine Glioma

Final Height and Body Mass Index among Adult Survivors of Childhood Brain Cancer: Childhood Cancer Survivor Study The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 10 4731-4739 Copyright Ã.© 2003 by The Endocrine Society James G. Gurney, Kirsten K. Ness, Marilyn Stovall, Suzanne Wolden, Judy A. Punyko, Joseph P. Neglia, Ann C. Mertens, Roger J

Craniopharyngioma and hypothalamic obesity in children Childs Nerv Syst. 2008 Dec 5

Desmoplastic infantile ganglioglioma: a questionably benign tumour Australas Radiol. 2005; 49(5):433-7 Taranath A; Lam A; Wong CK Department of Medical Imaging, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia, (requires Medscape account)

Inter-observer variability in the measurement of diffuse intrinsic pontine gliomas. Hayward RM, Patronas N, Baker EH, VÃ.©zina G, Albert PS, Warren KE. J Neurooncol. 2008 Oct;90(1):57-61. Epub 2008 Jun 28

Scientists Show How Brain Tumors Outsmart Drugs UC San Diego, News Center

Pediatric Brain Tumors and Nanotechnology This site provides information about nanotechnology. Nanotechnology is used to study the molecules (small biological particles) that can be delivered to brain tumors to successfully diagnose and treat this difficult cancer.

Auxologic and biochemical characterization of the three phases of growth failure in pediatric patients with brain tumors , J Pediatr Endocrinol Metab. 2004 May;17(5):711-7. Meacham LR, Mason PW, Sullivan KM.

Desmoplastic infantile ganglioglioma with a malignant course J Neurosurg Pediatrics. 2008 Jan;1(1):95-8

Phase II study, chemotherapy and radiation Chemotherapy and Radiation Therapy After Surgery in Treating Children with Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma (study completed)

Hypothalamic-pituitary function and growth in children with intracranial lesions, Brauner R, Adan L, Souberbielle JC.

Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint. Childs Nerv Syst. 2009 Apr;25(4):497-501. Epub 2009 Jan 13

Rapid discrimination of pediatric brain tumors by mass spectrometry imaging. Pub Med

Caring for the brain tumor patient: Family caregiver burden and unmet needs SNO-Oxford Journal.

Longterm treatment results of childhood medulloblastoma by craniospinal irradiation in supine position. Neoplasma. 2007;54(1):62-7. Slampa P, Pavelka Z, Dusek L, Hynkova L, Sterba J, Ondrova B, Princ D, Novotny T, Kostakova S.

MedicineNet.com Brain Tumor Index This site provide information about brain tumors and other cancer topics.

Etoposide, vincristine, and cyclosporin A with standard-dose radiation therapy in newly diagnosed diffuse intrinsic brainstem gliomas: a pediatric oncology group phase I study. Pediatr Blood Cancer. 2005 Oct 15;45(5):644-8.

Mayo Clinic-Brain Tumor Information

Impact of site of tumor recurrence upon survival for children with recurrent or progressive medulloblastoma Pub Med abstract: J Neurosurg. 2007 Jul;107(1 Suppl):5-10

Future Directions: R Packer Summary by Dr. R. J. Packer regarding future directions. HemOncToday, 9/25/08 .

Long-Term Neuromotor Speech Deficits in Survivors of Childhood Posterior Fossa Tumors: Effects of Tumor Type, Radiation, Age at Diagnosis, and Survival Years Abstract: Pub Med; J. Child Neurology, 2007 Jul;22(7):848-54.

Direct Orthotopic Transplantation of Fresh Surgical Specimen Preserves CD133+ Tumor Cells in Clinically Relevant Mouse Models of Medulloblastoma and Glioma Pud Med abstract: Stem Cells. 2008 Apr 10

Carboplatin hypersensitivity reaction in pediatric low grade glioma (LGG) patients: A national experience. On behalf of the Canadian Pediatric Brain Tumor Consortium, Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition).Vol 24, No 18S (June 20 Supplement), 2006: 9053 Ã.© 2006 American Society of Clinical Oncology

CT and MR imaging in atypical teratoid/rhabdoid tumors of the central nervous system, Neuroradiology. 2008 Mar 15

Experts Revive Debate Over Cellphones and Cancer Article in the New York Times, June 3, 2008

Efficacy of temozolomide for recurrent embryonal brain tumors in children. Childs Nerv Syst. 2008 Dec 24. [Epub ahead of print]

CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis, Pub Med abstract: Neurology. 2007 May 15;68(20):1668-73.

Incidence patterns for ependymoma: a Surveillance, Epidemiology, and End Results study J Neurosurg. 2008 Dec 5. [Epub ahead of print] Ependymoma occurs within the CNS at distinct locations at different ages, consistent with hypotheses postulating distinct populations of radial glial stem cells within the CNS. Ependymoma incidence appears to have increased over the past 3 decades, but only in adults.

Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy., J Clin Oncol. 2005 Mar 1;23(7):1491-9.

Development of testicular alpha-fetoprotein-secreting germ cell tumor 3 years after treatment of intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data–case report Neurol Med Chir (Tokyo). 2008;48(11):522-5

CT-322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan, RATIONALE: CT-322 may stop the growth of glioblastoma multiforme by blocking blood flow to the tumor. Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving CT-322 together with irinotecan may kill more tumor cells.

Both location and age predict survival in ependymoma: a SEER study. Pediatr Blood Cancer. 2009 Jan;52(1):65-9 McGuire CS, Sainani KL, Fisher PG

A scoring system to quantify late effects in children after treatment for medulloblastoma/ependymoma and its correlation with quality of life and neurocognitive functioning, Childs Nerv Syst. 2009 Feb;25(2):173-81. Epub 2008 Oct 30

Biological background of pediatric medulloblastoma and epedymoma: A review from a translational research perspective Judith M. deBont, Roger J. Packer; Erna Michiels, Monique L denBoer, and Rob Pieters; Neuro-Oncology, Duke University Press, 2008 10(6)

Designer therapies for glioblastoma multiforme Ann N Y Acad Sci. 2008 Oct;1142:108-32

Brain tumors in children and adolescents: Cognitive and psychological disorders at different ages, Psychooncology. 2005; 14(5):386-95 (ISSN: 1057-9249) (requires a Medscape account)

Human Brain: DIrections, cross-sections and divisions

HemOnc Today: Childhood Brain Tumors: Is the future now? RJ Packer

Long-term survival in children under 3 years of age with low-grade astrocytoma Childs Nerv Syst. 2007 May;23(5):543-7. Epub 2007 Jan 17 CONCLUSION: The only favorable prognostic pattern was the supratentorial presentation. Radiotherapy and chemotherapy did not alter the outcome.

A phase 2 feasibility study of sequential, dose intensive chemotherapy to treat progressive low-grade gliomas in children, J Pediatr Hematol Oncol. 2007 Sep;29(9):602-7

Initial Management of Childhood Brain Tumors: Neurosurgical Considerations J Child Neurol. 2008 Oct;23(10):1136-48

Gliomas in Neurofibromatosis Type 1: A Clinicopathologic Study of 100 Patients J Neuropathol Exp Neurol. 2008 Mar;67(3):240-9.

Brain Stem Gliomas Overview about brainstem gliomas.

Low-grade Astrocytoma Overview

Brain Tumor Progress Review Group Report 2000 PDF download. This article is a great reference to the barriers and priorities, many are still an issue.  Meetings specific to specific brain tumor groups.

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma

Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

ClinicalTrials.gov is a registry and result database of publicly and privately supported clinical studies of human participants conducted around the world.

Clinical Trials: Childhood Brain Stem Glioma

Prospective Study of Children and Adolescents With Craniopharyngioma

Clinical Trials for Diffuse Intrinsic Pontine Glioma: a Current State of Affairs 2020, Study for pediatric brain stem tumor.

Clinical Trials-Ependymoma ClinicalTrials.gov –Ependymoma

Clinical Trials-Medulloblastoma

Clinical Trials-Pediatric Low Grade Gliomas ClinicalTrials.gov, trials for pediatric low grade gliomas

Fred Hutch: Cancer Immunotherapy Trials Network

Health ‘passport’ provides guide for pediatric cancer survivors

Pediatric cancer survivors face lifetime of health challenges

Neuropsychology Central, Neuropsychology Central offers links and resources for a variety of brain disorders, including brain tumors and ADHD. This site offers links to other medical institutions for consultations and assessments.

Fred Hutch: Promising Experimental Therapies

National Institutes of Neurological Disorders and Stroke (NINDS)

Stanford Medicine/Monje Labs/Neurology and Neurological Sciences

Understanding Clinical Trials, Frequently asked questions

University of Miami School of Medicine, This neurosurgery site provides educational programs, research program, and information about conferences.

Juvenile pilocytic astrocytomas do not undergo spontaneous malignant transformation: grounds for designation as hamartomas. Parsa CF, Givrad S.1: Br J Ophthalmol. 2008 Jan;92(1):40-6. Epub 2007 Oct 25

Proton versus photon radiotherapy for common pediatric brain tumors: Comparison of models of dose characteristics and their relationship to cognitive function, Pub Med abstract: Pediatr Blood Cancer. 2008 Feb 27

Young Children Rely On One Sense Or Another, Not A Combination, Studies Find, ScienceDaily (May 1, 2008) – Unlike adults, children younger than eight can’t integrate different forms of sensory input to improve the accuracy with which they perceive the world around them, according to a pair of studies reported online in Current Biology, a publication of Cell Press, on May 1st.

LD Online, Understanding the Differences Between IDEA and Section 504 By: Council for Exceptional Children (2002)

Tumor antigens in astrocytic gliomas, Shekar N. Kurpad 1, X.-G. Zhao. 1, Carol J. Wikstrand 1, Surinder K. Batra 1, Roger E. McLendon 1, Dr. Darell D. Bigner 1 2

Brain Tumor Cells Killed by Anti-Nausea Drug, New research from the University of Adelaide has shown for the first time that the growth of brain tumors can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy.

Gene sequencing project discovers common driver of a childhood brain tumor

Emerging insights into barriers to effective brain tumor therapeutics

Study: Brain tumors hijack the brain’s existing blood supply during progression

Management of Pediatric Low-Grade Gliomas 2019

Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children’s Oncology Group phase II study. Korones DN, Fisher PG, Kretschmar C, Zhou T, Chen Z, Kepner J, Freeman C. Pediatr Blood Cancer. 2008 Feb;50(2):227-30

MRI: A WIndow to Genetic Properties of the Brain Article, ScienceDaily (3.36.08) about research findings from University of California, San Diego School of Medicine about MRI technology and its potential.

The treatment of high grade gliomas and diffuse intrinsic pontine tumors of childhood and adolescence: a historical – and futuristic – perspective Finlay JL, Zacharoulis S. J Neurooncol. 2005 Dec;75(3):253-66.

Tumor Painting Revoluntionizes Cancer Surgery: This article was posted in ScienceDaily, (July 19, 2007) referencing developments at Seattle Children’s Hospital Research Institute and Fred Hutchison Cancer Research Center. “Tumor Painting Revolutionizes Cancer Surgery: New Visiual Method 500 Times More Sensitive than MRI”

Temozolmide in pediatric low-grade gliomas An abstract posted on Pub Med. Pediatr Blood Cancer. 2007 Nov;49(6):808-11.

Management of chiasmatic-hypothalamic gliomas An abstract posted on Pub Med. No Shinkei Geka. 2007 Nov;35(11):1079-85.

NCI: Follow-up Care After Cancer Treatment: Questions and Answers Fact sheet

Intensive Multimodality Treatment for Children With Newly Diagnosed CNS Atypical Teratoid Rhabdoid Tumor. J Clin Oncol. 2008 Dec 8. [Epub ahead of print]

Proton Radiotherapy ffor childhood ependymoma: initial clinical outcomes and dose comparisons. Pub Med abstract: Int J Radiat Oncol Biol Phys. 2008 Mar 4

Preoperative functional magnetic resonance imaging assessment of higher-order cognitive function in patients undergoing surgery for brain tumors. J Neurosurg. 2008 Feb;108(2):258-68.

Germ Cell Tumors of the Gonads: A Selective Review Emphasizing Problems in Drug Resistance and Current Therapy Options Oncology. 2008 Dec 20;76(2):77-84

Initial management of childhood brain tumors: neurosurgical considerations J Child Neurol. 2008 Oct;23(10):1136-48

Management of and prognosis with medulloblastoma: therapy at a crossroads Arch Neurol. 2008 Nov;65(11):1419-24

Vaccine May Double Survival In Patients With Deadly Brain Tumors “ScienceDaily (Jun. 3, 2008) – A vaccine aimed at inducing immunity to the most common and deadly type of brain tumor may stave off recurrence and more than double survival in patients, according to a new study led by researchers in Duke’s Preston Robert Tisch Brain Tumor Center.”

Needy Meds A resource for individuals who do not have health insurance or cannot afford their medications. This site provide information for patient assistance programs and other resources.

Screening and Diagnosis of Optic Pathway Gliomas in Children with Neurofibromatosis Type 1 by Using Investigative Ophthalmology & Visual Science, June 2007, Vol. 48, No. 6 Copyright Ã.© Association for Research in Vision and Ophthalmology

Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncol. 2007 Aug;8(8):685-95.Related Articles, Links

Tandem Duplication Producing a Novel Oncogenic BRAF Fusion Gene Defines the Majority of Pilocytic Astrocytomas Cancer Research 68, 8673-8677, November 1, 2008. doi: 10.1158/0008-5472.CAN-08-2097 Ã.© 2008 This is the first report of BRAF activation through rearrangement as a frequent feature in a sporadic tumor. The frequency and specificity of this change underline its potential both as a therapeutic target and as a diagnostic tool.