Angiogenesis Inhibitors – An “Old Frontier” in Cancer Therapy
by Tobey MacDonald, M.D., Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA In 1971, Dr. Judah Folkman, then surgeon-in-chief of Children’s Hospital Boston, reported in the New England Journal of Medicine that solid tumors are dependent on “angiogenesis”, the formation of new blood vessels, for survival and growth. He proposed that …