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brain tumors

High-Grade Gliomas

03/01/2020 by Jeanne Young

Normal brain is made up of several cell types including neurons, the main functional cell of the brain, and glia, which play a supportive role to the neurons. Glia are further subdivided into different types, each type with a different function, including oligodendrocytes which cover the axons of neurons with sheathes of myelin, and astrocytes …

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Impact of New Molecular Understandings on Brain Tumor Clinical Trial Design Performance

02/25/2020 by Jeanne Young

Dr. Roger J. Packer The Childhood Brain Tumor Foundation was pleased to be a Silver Sponsor for the comprehensive 17th International Symposium on Pediatric Neuro-Oncology. Our Neurotransmitter Fall-Winter edition will cover other topics from the other conference. This summary covers a topic from Family Day and Educational Day, held June 11, 2016, related to molecular …

Read moreImpact of New Molecular Understandings on Brain Tumor Clinical Trial Design Performance

Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials

02/07/2020 by Jeanne Young

LINK TO ARTICLE: Stanford Medicine/Monje Labs/Neurology and Neurological Sciences

Read moreDiffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials

Infantile Brain Tumors

01/20/2020 by Jeanne Young

Brain tumors are the second most common type of malignancy in children less than 2 years of age. Furthermore, brain tumors as a whole are the most common solid tumor of childhood and 12-15% of all childhood brain tumors occur in children less than two. Childhood brain tumors occur in males more frequently than in …

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Proteomics

01/20/2020 by Jeanne Young

Over the last decade, there has been an explosion in the amount of data generated from the DNA and RNA sequencing studies. Essentially, these data inform us about the blueprints of the cancer cell – the instructions it uses to carry out its primary function of cellular proliferation. However, translating these findings into new therapies …

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Why Research is Important to Me

12/30/2019 by Jeanne Young

John Y.H. Kim, MD, Baylor College of Medicine, Houston, TX Pediatrics became the focus of my clinical interests because of its intrinsic orientation toward developmental issues. I have since had the great fortune of serving children and their families who have charged me with my life’s work. No group of patients and families appeared to …

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Neurotoxicity

12/27/2019 by Jeanne Young

Changes in the Brains of Children with Brain Tumors of the Central Nervous System Neurotoxicity is a significant tumor-and treatment-related complication for a number of childhood cancer survivors. It is particularly relevant for children with brain tumors who require therapy specifically directed at the central nervous system. Despite its significance, relatively little is known about …

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Angiogenesis Inhibitors: A New Frontier in Cancer Therapy

12/17/2019 by Jeanne Young

Tobey J. MacDonald, M.D. For over 50 years, the field of cancer therapy has been dominated by the concept that the tumor must be the selected target of the chemotherapy delivered. Therefore, any drug with the ability to directly kill tumor cells in the laboratory was by definition a candidate for use as chemotherapy in …

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Ependymomas

12/17/2019 by Jeanne Young

Kathy Warren, MD, pediatric oncologist, National Cancer Institute INTRODUCTION: Although ependymomas are the third most common type of brain tumor in children (following astrocytoma and medulloblastoma), they are relatively rare, with approximately 200 cases diagnosed in the US each year in children and adults less than 25 years of age. Ependymomas account for 6-12% of …

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