Maral Adel Fahmideh, PhD; Michael E. Scheurer, PhD, MPH, Baylor College of Medicine Introduction Primary brain tumors are the most common solid tumors in children and the leading cause of cancer mortality in this population. Pediatric brain tumors (PBTs) are heterogeneous in histopathology, molecular features, and prognosis, and they are classified into two major categories including …
Changes in the Brains of Children with Brain Tumors of the Central Nervous System Neurotoxicity is a significant tumor-and treatment-related complication for a number of childhood cancer survivors. It is particularly relevant for children with brain tumors who require therapy specifically directed at the central nervous system. Despite its significance, relatively little is known about …
Leigh Marcus, M.D., National Cancer Institute Special Project funded 2010-2011 We would like to thank the CBTF for supporting our phase 1 clinical trial of Satraplatin in children with brain tumors. Although overall survival for children with CNS tumors is rising, new agents that are more effective and less toxic are desperately needed. Chemotherapeutic agents …
Medulloblastoma is the most common primary malignant central nervous system tumor arising in childhood. Survival rates for children with medulloblastomas have nearly doubled and so has the recognition that many survivors are impaired and new forms of treatment are needed. Its understanding and management represents both the progress and challenges involved in the treatment of …
by David M. Panchision, Ph.D., Investigator, Center for Neuroscience Research, Children’s National Medical Center, Washington, DC Central Nervous System (CNS) tumors are one of the most prevalent forms of cancer in the U.S. and are the leading cause of cancer deaths in children (1-3). Current therapies can affect all cells, as with radiation, or highly …