As the care of children with brain tumors evolves, there is recognition that despite advances in surgery, chemotherapy and radiation therapy, there are clear needs to explore other options and to create mechanisms where new therapeutic approaches can be assessed carefully and expeditiously. Over the past 2 decades, multiple clinical trials consortia have been developed …
Dr. Roger J. Packer The Childhood Brain Tumor Foundation was pleased to be a Silver Sponsor for the comprehensive 17th International Symposium on Pediatric Neuro-Oncology. Our Neurotransmitter Fall-Winter edition will cover other topics from the other conference. This summary covers a topic from Family Day and Educational Day, held June 11, 2016, related to molecular …
LINK TO ARTICLE: Stanford Medicine/Monje Labs/Neurology and Neurological Sciences
Daniel W. Lee, MD, University of Virginia Cancer Center Charlottesville One-year study, final summary 2019 Dr. Lee and his lab set out to develop a brand new tool to effectively treat children with DIPG. Using Chimeric Antigen Receptor (CAR) T cells, a therapy he helped pioneer in children with refractory leukemia, Dr. Lee’s lab designed, …
Carl D. Novina, M.D., Ph.D.Dana-Farber Cancer Institute NEW-first of two-years 2019-2020 “The central organizing idea of biology (dogma) is that DNA (the blueprint of a cell), makes RNA (a messenger of information contained in the DNA) which in turn makes proteins (which carry out the activities of a cell). Whereas most scientists and physicians study …
Stephen C. Mack, Ph.D., Baylor College of Medicine, Texas Children’s one-year study, final summary We are grateful for support provided by the CBTF and funders that have allowed us to pursue our project on the characterizing “The Role of MOS Proto-Oncogene in H3.3K27M Diffuse Intrinsic Pontine Glioma”. Diffuse intrinsic pontine glioma (DIPG) remains a fatal …
Paul Graham Fisher, M.D., M.H.S. and Michelle Monje, M.D., Ph.D Brain stem tumors are perhaps the most dreaded cancers in pediatric oncology, owing to their historically poor prognosis, yet they remain an area of intense research. Brain stem tumors account for about 10 to 15% of childhood brain tumors. Peak incidence for these tumors occurs …
PI: J. Bryan Iorgulescu, Weill Cornell Medical College, 2011-2012 I have a deep-seated passion for pediatric neuro-oncology research and wish to pursue a career where I can directly fight children’s brain cancers – & hopefully one day, help find a cure. Delving into this project along side my medical school studies at Weill Cornell Medical …
Charles Eberhart, M.D., Ph.D. 2010-2011 funding Diffuse intrinsic pontine gliomas (DIPG) are among the most deadly pediatric brain cancers, with no effective therapies. Unfortunately, few models for these exist, severely limiting our ability to test new treatments for the patients who need them most. The goal of our research proposal is to develop accurate models …
