Kathy Warren, M.D., NCI Special Project funded 2010-2011 Children with diffuse intrinsic pontine gliomas (DIPG) continue to have a poor outcome despite advances in radiation oncology, new chemotherapeutic agents and extensive research into overcoming drug resistance. One of the major obstacles is the lack of biological studies that may aid us in better understanding the …
Background Primary CNS tumors are the most common pediatric solid cancer, and account for 23% of malignancy in children under 15 years of age, second only to leukemia. The incidence of newly diagnosed brain tumors in the pediatric population is 3.3 cases per 100,000 children, with 3,000 children diagnosed annually. Brain tumors are also the …
Philip Beachy, Ph.D. and Michelle Monje, M.D. 2010-2011 funding Diffuse intrinsic pontine glioma (DIPG) is a devastating childhood brain tumor that is poorly understood and universally fatal. Progress to date has been limited by a lack of faithful experimental model systems. We have overcome this impasse by generating new DIPG cell lines and xenograft model …
Javad Nazarian, Ph.D., Assistant Professor, Pediatrics, Children’s National Medical Center, Center for Genetic Medicine The focus of my science career changed almost three years ago when a physician colleague approached me and proposed a potentially challenging project: molecular analysis of pediatric brainstem gliomas (BSGs). The project deemed challenging because of the lack of fresh frozen …
