glioblastoma

Braf Mutation Effects on Malignant Astrocytoma

Abstract: CD133+ subpopulations of cells in glioblastoma (GBM) show in vivo resistance to treatment with radiation and temozolomide, and are thought to contribute to therapy evasion and tumor recurrence. Frequent hyperactivation of the MAPK pathway in GBM has prompted the clinical evaluation of several pharmacological MAPK pathway inhibitors for the treatment of GBM. Here we …

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Reciprocal Regulation of Electroresponsiveness between Glioblastoma and Brain

2016 Summary Principal investigators: Dimitris Placantonakis and Jayeeta Basu, NYU School of Medicine Glioblastoma (GBM) is a deadly brain tumor affecting children and adults. The biology of GBM is not well understood and, as a consequence, treatments are limited and ineffective. GBM grows rapidly and invades normal brain tissue, but never metastasizes to other organs. …

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