Changes in the Brains of Children with Brain Tumors of the Central Nervous System Neurotoxicity is a significant tumor-and treatment-related complication for a number of childhood cancer survivors. It is particularly relevant for children with brain tumors who require therapy specifically directed at the central nervous system. Despite its significance, relatively little is known about …
Kathy Warren, MD, pediatric oncologist, National Cancer Institute INTRODUCTION: Although ependymomas are the third most common type of brain tumor in children (following astrocytoma and medulloblastoma), they are relatively rare, with approximately 200 cases diagnosed in the US each year in children and adults less than 25 years of age. Ependymomas account for 6-12% of …
Kathy Warren, M.D., NCI Special Project funded 2010-2011 Children with diffuse intrinsic pontine gliomas (DIPG) continue to have a poor outcome despite advances in radiation oncology, new chemotherapeutic agents and extensive research into overcoming drug resistance. One of the major obstacles is the lack of biological studies that may aid us in better understanding the …