Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials
LINK TO ARTICLE: Stanford Medicine/Monje Labs/Neurology and Neurological Sciences
Michelle Monje MD PhD
Brain Stem Gliomas in Childhood
Paul Graham Fisher, M.D., M.H.S. and Michelle Monje, M.D., Ph.D Brain stem tumors are perhaps the most dreaded cancers in pediatric oncology, owing to their historically poor prognosis, yet they remain an area of intense research. Brain stem tumors account for about 10 to 15% of childhood brain tumors. Peak incidence for these tumors occurs …
The Hedgehog Pathway in Diffuse Intrinsic Pontine Glioma
Philip Beachy, Ph.D. and Michelle Monje, M.D. 2010-2011 funding Diffuse intrinsic pontine glioma (DIPG) is a devastating childhood brain tumor that is poorly understood and universally fatal. Progress to date has been limited by a lack of faithful experimental model systems. We have overcome this impasse by generating new DIPG cell lines and xenograft model …