National Cancer Institute

Phase I and Pharmacokinetic study of Satraplatin in children with recurrent or refractory solid tumors, including CNS tumors

Leigh Marcus, M.D., National Cancer Institute Special Project funded 2010-2011 We would like to thank the CBTF for supporting our phase 1 clinical trial of Satraplatin in children with brain tumors.  Although overall survival for children with CNS tumors is rising, new agents that are more effective and less toxic are desperately needed.  Chemotherapeutic agents …

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Histologic and Genomic Evaluation of Diffuse Intrinsic Pontine Gliomas and Supratentorial Gliomas

Kathy Warren, M.D., NCI Special Project funded 2010-2011 Children with diffuse intrinsic pontine gliomas (DIPG) continue to have a poor outcome despite advances in radiation oncology, new chemotherapeutic agents and extensive research into overcoming drug resistance.  One of the major obstacles is the lack of biological studies that may aid us in better understanding the …

Read moreHistologic and Genomic Evaluation of Diffuse Intrinsic Pontine Gliomas and Supratentorial Gliomas