pediatric gliomas

Functional Analysis of the H3.3‐K27M mutation in pediatric glioma

Marius Wernig, M.D., Ph.D. Stanford University School of Medicine The lysine 27 to methionine substitution in histone variant H3.3 (H3.3-K27M) is the most common mutation in pediatric high grade gliomas. Recent studies have demonstrated that this mutation leads to a global reduction of H3K27 trimethylation in a dominant manner by sequestering an enzymatic subunit of …

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Molecular Studies of Pediatric Brainstem Gliomas

Javad Nazarian, Ph.D., Assistant Professor, Pediatrics, Children’s National Medical Center, Center for Genetic Medicine The focus of my science career changed almost three years ago when a physician colleague approached me and proposed a potentially challenging project: molecular analysis of pediatric brainstem gliomas (BSGs).  The project deemed challenging because of the lack of fresh frozen …

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