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pediatric high-grade gliomas

Targeting H3.3 Mutations in Pediatric HGG

12/01/2019 by Jeanne Young

Brendan Price, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. Pediatric high-grade gliomas (pHGG) have few treatment options and most children diagnosed only survive for 1-2 years. Identifying new treatments is therefore of the highest priority. Work in the lab is focused on understanding how these brain tumors arise, with the …

Read moreTargeting H3.3 Mutations in Pediatric HGG

Repurposing low-dose quinolone methanol derivatives as a novel treatment for pediatric high grade gliomas

02/01/2019 by Jeanne Young

Jian Teng, Ph.D., Massachusetts General Hospital one-year 2018-2019 final summary I want to take this opportunity to sincerely thank CBTF for your funding to my proposal of using a subset of quinoline methanol anti-malaria agents in killing pediatric brain cancer cells. This funding helps us get one step closer to our goal. With the funding …

Read moreRepurposing low-dose quinolone methanol derivatives as a novel treatment for pediatric high grade gliomas

Multispecific CAR T cells for the Treatment of High Grade Gliomas in Children

11/01/2018 by Jeanne Young

Kevin Bielamowicz Poor outcomes for children with high grade glioma (HGG) warrant novel therapeutic strategies, and redirecting immune cells can achieve this aim while minimizing side effects to normal cells. Using mathematical modeling in a group of brain tumor samples, we discovered substantial variation between individual cells within the same tumor as well as between …

Read moreMultispecific CAR T cells for the Treatment of High Grade Gliomas in Children

Multispecific CAR T cells for the Treatment of High Grade Gliomas in Children

07/15/2016 by Jeanne Young

Kevin Bielamowicz, M.D., Arkansas Research Institute 2016, second year Poor outcomes for children with high grade glioma (HGG) warrant novel therapeutic strategies, and redirecting immune cells can achieve this aim while minimizing side effects to normal cells. Using mathematical modeling in a group of brain tumor samples, we discovered substantial variation between individual cells within …

Read moreMultispecific CAR T cells for the Treatment of High Grade Gliomas in Children

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