Over the last decade, there has been an explosion in the amount of data generated from the DNA and RNA sequencing studies. Essentially, these data inform us about the blueprints of the cancer cell – the instructions it uses to carry out its primary function of cellular proliferation. However, translating these findings into new therapies …
NEW RESEARCH STUDY A protocol is open at the Pediatric Oncology Branch of the National Cancer Institute, National Institutes of Health, for children, ages 8 to 18 years, who have had a brain tumor that was treated with radiation at least 1 year ago. This study is evaluating whether a novel home physical activity program …
by Tobey MacDonald, M.D., Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA In 1971, Dr. Judah Folkman, then surgeon-in-chief of Children’s Hospital Boston, reported in the New England Journal of Medicine that solid tumors are dependent on “angiogenesis”, the formation of new blood vessels, for survival and growth. He proposed that …
A new protocol is open at the Pediatric Oncology Branch of the National Cancer Institute for children, ages 8 to 17 years, who have had a brain tumor that was treated with radiation at least 2 years ago. This study is evaluating whether a novel home physical activity program improves cognitive late effects, which may …
Paul Graham Fisher, M.D., M.H.S. and Michelle Monje, M.D., Ph.D Brain stem tumors are perhaps the most dreaded cancers in pediatric oncology, owing to their historically poor prognosis, yet they remain an area of intense research. Brain stem tumors account for about 10 to 15% of childhood brain tumors. Peak incidence for these tumors occurs …
Low-grade gliomas are the most common brain tumor in children. Although some patients can be effectively cured with surgery alone, recurrences are common in a significant majority of patients—especially those without neurofibromatosis type I (NF1). These patients often require repeated resections, chemotherapy and often radiation therapy. The damage caused by these therapies has a significant …
