Targeting MYC Driven Medulloblastoma with Combinatorial Immune Checkpoint Blockade.
Allison Martin, M.D. Medulloblastoma is the most common malignant brain tumor in children. In cases of relapsed or refractory disease there is no known curative therapy. To address this question we have generated fetal mouse brain cells that mimic the most aggressive phenotype of medulloblastoma called “anaplastic” when they are placed into the cerebellum of …