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The Hedgehog Pathway

The Roles of O-GlcNAcyulation in the Hedgehog Pathway in Medulloblastoma

07/01/2019 by Jeanne Young

Huadong Pei, Ph.D., The George Washington University New Funding Summary, first of two years Medulloblastoma is the most common and aggressive type of brain tumor in children. It originates in the back part of the brain called the cerebellum. In up to 1/3 of cases, it can spread to other parts of the brain and …

Read moreThe Roles of O-GlcNAcyulation in the Hedgehog Pathway in Medulloblastoma

The Hedgehog Pathway in Diffuse Intrinsic Pontine Glioma

07/01/2010 by Jeanne Young

Philip Beachy, Ph.D. and Michelle Monje, M.D. 2010-2011 funding Diffuse intrinsic pontine glioma (DIPG) is a devastating childhood brain tumor that is poorly understood and universally fatal.  Progress to date has been limited by a lack of faithful experimental model systems. We have overcome this impasse by generating new DIPG cell lines and xenograft model …

Read moreThe Hedgehog Pathway in Diffuse Intrinsic Pontine Glioma

Hedgehog Pathway Activation in Juvenile Pilocytic Astrocytoma

05/01/2008 by Jeanne Young

Michael Cooper Funded 2008 Pilocytic astrocytoma is commonly viewed as a benign lesion with an excellent 10-year survival rate. However, disease onset is most prevalent in the first two decades of life, current therapeutic modalities are often limited by tumor location and size and late recurrences are not uncommon. Thus, as many children are left …

Read moreHedgehog Pathway Activation in Juvenile Pilocytic Astrocytoma

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