Maral Adel Fahmideh, PhD; Michael E. Scheurer, PhD, MPH, Baylor College of Medicine Introduction Primary brain tumors are the most common solid tumors in children and the leading cause of cancer mortality in this population. Pediatric brain tumors (PBTs) are heterogeneous in histopathology, molecular features, and prognosis, and they are classified into two major categories including …
Normal brain is made up of several cell types including neurons, the main functional cell of the brain, and glia, which play a supportive role to the neurons. Glia are further subdivided into different types, each type with a different function, including oligodendrocytes which cover the axons of neurons with sheathes of myelin, and astrocytes …
As the care of children with brain tumors evolves, there is recognition that despite advances in surgery, chemotherapy and radiation therapy, there are clear needs to explore other options and to create mechanisms where new therapeutic approaches can be assessed carefully and expeditiously. Over the past 2 decades, multiple clinical trials consortia have been developed …
Dr. Roger J. Packer The Childhood Brain Tumor Foundation was pleased to be a Silver Sponsor for the comprehensive 17th International Symposium on Pediatric Neuro-Oncology. Our Neurotransmitter Fall-Winter edition will cover other topics from the other conference. This summary covers a topic from Family Day and Educational Day, held June 11, 2016, related to molecular …
LINK TO ARTICLE: Stanford Medicine/Monje Labs/Neurology and Neurological Sciences
Over the last decade, there has been an explosion in the amount of data generated from the DNA and RNA sequencing studies. Essentially, these data inform us about the blueprints of the cancer cell – the instructions it uses to carry out its primary function of cellular proliferation. However, translating these findings into new therapies …
Brain tumors are the second most common type of malignancy in children less than 2 years of age. Furthermore, brain tumors as a whole are the most common solid tumor of childhood and 12-15% of all childhood brain tumors occur in children less than two. Childhood brain tumors occur in males more frequently than in …
by Tobey MacDonald, M.D., Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA In 1971, Dr. Judah Folkman, then surgeon-in-chief of Children’s Hospital Boston, reported in the New England Journal of Medicine that solid tumors are dependent on “angiogenesis”, the formation of new blood vessels, for survival and growth. He proposed that …
Jonathan L. Finlay, MB ChB, FRCP (Lond.), FRCPCH, Director, Neuro-oncology Program; Elizabeth and Richard Germain Endowed Professor of Pediatric Cancer, Division of Peduiatric Hematology, Oncology and Blood & Marrow Transplant, Nationwide Children’s Hospital. Professor of Pediatrics and Radiation Oncology, The Ohio State University, Columbus, Ohio, USA The family of tumors known as germ cell tumors …
