research
Geoff Cornman Memorial Golf Tournament
Thank you to all of our participants, donors and sponsors of this event! For more information about the event, visit our Fall 2024 Newsletter publication.
Pediatric Brain Tumor National and International Clinical Trials Consortia: an Overview
As the care of children with brain tumors evolves, there is recognition that despite advances in surgery, chemotherapy and radiation therapy, there are clear needs to explore other options and to create mechanisms where new therapeutic approaches can be assessed carefully and expeditiously. Over the past 2 decades, multiple clinical trials consortia have been developed …
Researching Childhood Brain Tumors
Gary Tye, M.D., Virginia Commonwealth University In my practice as a pediatric neurosurgeon I see children afflicted with brain tumors on a regular basis, either for surgery or in the many required follow-up visits. Despite our best standards of care, many of these children, assuming they survive their cancer, may suffer severe developmental and cognitive …
Physical Activity for Cognitive Effects – NEW RESEARCH STUDY
A new protocol is open at the Pediatric Oncology Branch of the National Cancer Institute for children, ages 8 to 17 years, who have had a brain tumor that was treated with radiation at least 2 years ago. This study is evaluating whether a novel home physical activity program improves cognitive late effects, which may …
Rapid Development of Chimeric Antigen Receptors (CARs) for DIPG
Daniel W. Lee, MD, University of Virginia Cancer Center Charlottesville One-year study, final summary 2019 Dr. Lee and his lab set out to develop a brand new tool to effectively treat children with DIPG. Using Chimeric Antigen Receptor (CAR) T cells, a therapy he helped pioneer in children with refractory leukemia, Dr. Lee’s lab designed, …
A Novel Mechanism and Immediately-Translatable Targeted Therapy Group 3 MB
Yin Wang, Ph.D. First-year Children’s National, DC; University of Maryland, Baltimore Two-year study, second year Dr. Wang’s group has made significant progress for their project, “A Novel Mechanism and Immediately-Translatable Targeted-Therapy for Group 3 Medulloblastoma”. Their completed studies have demonstrated that HIF1α is a driver for infant Group 3 medulloblastoma (G3MB) by reciprocal positive regulation …
The Roles of O-GlcNAcyulation in the Hedgehog Pathway in Medulloblastoma
Huadong Pei, Ph.D., The George Washington University New Funding Summary, first of two years Medulloblastoma is the most common and aggressive type of brain tumor in children. It originates in the back part of the brain called the cerebellum. In up to 1/3 of cases, it can spread to other parts of the brain and …
Defining LncRNA-Transcription Factor Networks in Diffuse Intrinsic Pontine Glioma
Carl D. Novina, M.D., Ph.D.Dana-Farber Cancer Institute NEW-first of two-years 2019-2020 “The central organizing idea of biology (dogma) is that DNA (the blueprint of a cell), makes RNA (a messenger of information contained in the DNA) which in turn makes proteins (which carry out the activities of a cell). Whereas most scientists and physicians study …